S100A8 and Sepsis: Comprehensively considering the fold change (>1.5 or <0.5) and a P-value <0.05, the biological effects of the distinct proteins and involvement of proteins in the induction of inflammation and sepsis, five proteins were selected for further gene network analysis, including apolipoprotein E (ApoE), annexin A1 (Anxa1), neutrophil gelatinase-associated lipocalin (NGAL), S100a8 and S100a9 (Fig. 5).