MAPT and Alzheimer disease: (Macro)autophagy is a critical clearancepathway for organelles and long-lived proteins, including intracytoplasmicaggregate-prone proteins that cause many neurodegenerative diseases, such ashuntingtin inHuntington’s disease and tau in AD (reviewed in ref. 2).Furthermore, autophagy protects cells against proapoptotic insults by reducing caspaseactivation3.