SIX1 and open-angle glaucoma: In addition to confirming the previously published CDKN2BAS and SIX1/6 POAG risk loci, we found nominally significant (P<0.05) associations with POAG for six newly identified genetic variants (P=8.1 × 10−5 from binomial test for chance of seeing six or more such nominally significant associations in 16 tests) (Supplementary Table 8), with odds ratios varying between 0.73 and 1.20.