Another example of a physiologically important partnering of GATA4 was provided by the finding that the G296S mutation affects the interaction between GATA4 and Tbx5 and it leads to congenital heart disease in patients (Garg et al., 2003), while in homozygous mutant mice it causes mid-gestation lethality (Misra et al., 2012). Here, TBX5 is linked to congenital heart disease.