In further support of this, analysis of the transcriptomic profiles of a publically available dataset (Taylor et al., 2010) of prostate cancer (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE21034) shows high p23 expression in prostate tumours correlated with decreased overall survival (Supplementary Figure S2B). Here, PTGES3 is linked to Familial prostate cancer.