NFKB1 and familial pancreatic carcinoma: Additionally, the expression of p65 (a subunit of heterodimeric NF-κB complexes) and caspase-3 (a proapoptotic protein) was evaluated in 14 pancreatic cancer tissue samples by western blotting, presenting that there was a constitutional expression of p65 and caspase-3 proteins in examined specimens, and high level of caspase-3 expression was associated with low p65 expression (r = −0.634, P = 0.027; Figure 1F).