To dissect the roles of macrophage Akt1 and Akt2 isoforms in atherosclerosis, 10-week-old female Ldlr−/− mice were lethally irradiated and transplanted with female WT (n = 9), Akt1−/− (n = 10), or Akt2−/− (n = 10) FLCs. The gene discussed is AKT2; the disease is atherosclerosis.