has shown that adrenal hyperplasia observed in IHA patients was immunoreactive for type I 3β-hydroxysteroid dehydrogenase (HSD3B1), whereas APA was immunoreactive for type II 3β-hydroxysteroid dehydrogenase (HSD3B2), not for HSD3B1. This evidence concerns the gene HSD3B1 and congenital adrenal hyperplasia.