Interestingly, some of the associations we observed were only significant in the phenotypic subgroup for which the risk variant was originally reported; for example, APOE genotypes only affected survival after onset in our subgroup of C9ORF72 expansion carriers with FTD, whereas the UNC13A variant only affected survival after onset in our MND subgroup. The gene discussed is APOE; the disease is frontotemporal dementia.