In particular, SDHBIHC-/SDHAIHC- GIST include a subgroup of young adult women patients with a well defined clinical and biological profile, generally characterized by the gastric primary tumour localization, a predominantly mixed epithelioid and spindle cell morphology, diffuse IHC positivity for KIT and discovered on gastrointestinal stromal tumours 1 (DOG1), frequent lymph node metastases, and an indolent course of disease even if metastasis is present [17]. The gene discussed is KIT; the disease is gastrointestinal stromal tumor.