A further phase 3 clinical trial in patients with ALK-positive NSCLC confirmed the advantage of crizotinib in survival, response rates, and duration of response in ALK-positive patients with NSCLC, although mild to severe adverse effects, commonly reported as gastrointestinal disturbances (nausea, diarrhea, vomiting, and constipation), visual disturbances and fatigue, were noted[15, 16]. This evidence concerns the gene ALK and non-small cell lung carcinoma.