At the KCNQ1 locus (Fig. 1), meta-analysis of densely typed genetic variants from Metabochip fine-mapping regions in 34,840 T2D cases and 114,981 controls, primarily of European ancestry, revealed two signals of association at genome-wide significance that localised to different recombination intervals, represented by: rs163184 (p = 1.2 × 10−11), which maps to an intron of the gene, and rs231361 (p = 1.2 × 10−9), which resides in the KCNQ1-OT1 transcript that controls regional imprinting [8•]. The gene discussed is KCNQ1; the disease is type 2 diabetes mellitus.