Kosaki et al. [33] reported a SGBS patient with hepatoblastoma and a CTNNB1 somatic mutation (p.Ile35Ser) together with a germline loss-of function mutation in GPC3. Since the CTNNB1 mutation in the tumor tissue represents a driver mutation, these data suggest that mutation in GPC3 may influence one of the initial steps in tumorigenesis and the progression to hepatoblastoma. Here, GPC3 is linked to neoplasm.