After the confirmation of IL-8 expression in tumor conditioned medium (TCM) by a cytokine array assay performed to explore changes in the profile of chemokines secreted by tumors (Fig. 3, b) we observed that only LMW HA pre-treatment decreased by 50% the fraction of DC that migrated toward human recombinant IL-8 (Fig. 4, a). The gene discussed is CXCL8; the disease is neoplasm.