To further understand mechanisms involved in LMW HA effects on DC we analyzed the CCL21/CCR7 axis and found an increased ability to migrate toward CCL21 in DC/TL/LMW HA in vitro when compared to DC/TL condition, in both HD or CRC patients (38% and 25%, respectively; p≤0,01) (Fig. 2, a). This evidence concerns the gene CCR7 and colorectal carcinoma.