However, in a recent study using these selected polymorphisms only the C-allele of the single nucleotide polymorphism (SNP) rs6136-SELP was found to be associated with weight loss of >10%, both in the first study cohort of 775, including 114 PDAC patients, and in the validation cohort of 101 cancer patients, including 6 PDAC patients [16]. The gene discussed is SELP; the disease is cancer.