However, the variable predisposition to cachexia may be also due to the patient's genotype, and a comprehensive pharmacogenetic study demonstrated the association of cachexia with the rs6136 polymorphism of the gene SELP. This gene encodes the cell adhesion protein P-selectin, which was found to be upregulated in murine and rats models of cachexia caused by both acute and chronic inflammatory insults [16]. This evidence concerns the gene SELP and Cachexia.