It is also known that, in obesity, the hypertrophic adipose tissue becomes infiltrated with pro-inflammatory macrophages, produces more pro-inflammatory cytokines and less adiponectin (an anti-inflammatory adipokine) and contributes to the systemic complications of obesity, including diabetes type 2 and MS, as well as to increased cardiovascular risk in these populations [37]–[38]. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.