A study involving 417 Costa Rican children and 503 children participating in a childhood asthma management program showed significant changes in the interaction between IgE and dust mite allergens at three IL10 SNP positions (rs1800896, rs3024492, and rs3024496), suggesting that exposure to these allergens significantly modified the effect of IL10 SNPs [43]. This evidence concerns the gene IGHE and asthma.