IL2 and allergic disease: IL2 at position −330 showed a significant association with three clinical forms of allergic disease (asthma, allergic rhinitis, and atopic dermatitis) in the group with 135 families, with p-values between 0.01 and 0.05, and IL2 at position +166 also showed a significant association (with a p-value of 0.0005) in the same group.