In another seminal paper, Yang MH et al. showed that TWIST1 regulates the polycomb-group protein Bmi1 and that both TWIST1 and Bmi1 were mutually essential to promote EMT and repress expression of E-cadherin and p16INK4a in head and neck cancers, with the up-regulation of both proteins conferring the worst prognosis for patients [72]. This evidence concerns the gene BMI1 and head and neck cancer.