In a recent study by Kristensen  et al. [15], highly cancer-specific aberrant promoter hypermethylation and significantly downregulated expression levels were observed in PC compared to nonmalignant prostate tissue, indicating that aberrant promoter hypermethylation is associated with coordinated downregulation of the entire GABRE~miR-452~miR-224 locus in PC. The gene discussed is GABRE; the disease is pachyonychia congenita.