GSTP1 and pachyonychia congenita: In a recent NGS study, Lin et al. [78] used enhanced reduced representation bisulfite sequencing (eRRBS) to investigate DNA methylation at >2.5 million single CpG sites in seven matched pairs of PC and non-malignant tissue samples as well as six CRPC specimens with neuroendocrine phenotype, leading to the identification of a panel of 13 gene-associated CGIs (GSTP1, GRASP, TMP4, KCNC2, TBX1, ZDHHC1, CAPG, RARRES2, SAC3D1, NKX2-1, FAM107A, SLC13A3, FILIP1L) that exhibited increased methylation in disease progression concurrent with downregulation of expression.