RP: Radical prostatectomy; TURP: Transurethral resection of the prostate; FFPE: Formalin-fixed, paraffin embedded; FF: Fresh frozen; MSP: Methylation-specific PCR; qMSP: Quantitative MSP; BCR: Biochemical recurrence; HR: Hazard ratio; OR: Odds ratio; 95% CI: 95% confidence interval; NA: Not available; GS: Gleason score; pT: pathological tumor stage; SM: Surgical margin status; PSA: Pre-operative serum PSA; EP: Extracapsular penetration; pN: Pathological lymph node status; SV: Seminal vesicles involvement. The gene discussed is KLK3; the disease is neoplasm.