Collagen triple helix repeat containing-1 (CTHRC1) was found to be ubiquitously expressed in numerous cell types such as fibroblasts and smooth muscle cells, and aberrantly up-regulated in several malignant tumors, including melanoma, and cancers of the gastrointestinal tract, breast, thyroid, liver and the pancreas [14–19]. Here, CTHRC1 is linked to melanoma.