Moreover, knock-down and ectopic expression of CTHRC1 showed that CTHRC1 promoted the invasion and migration of NSCLC cells in vitro via the Wnt/β-catenin signaling pathway, and this is further verified by the correlation analysis between CTHRC1 expression and both lymph node and distant metastasis in archived patient samples. This evidence concerns the gene CTHRC1 and non-small cell lung carcinoma.