Moreover, the density of intra-tumoral mDC infiltrating cells was correlated with the main clinical, pathological and laboratory parameters, including age (inverse correlation), sex (higher in women), smoking status (lower in smokers), COPD status (lower in COPD patients), ASA score (lower in higher classes), histology (lower in squamous cell carcinoma), nutritional parameters (body weight, BMI, prealbumin and albumin levels, nutritional risk index), CRP levels (negative correlation), as well as with CD8+ T cells density. The gene discussed is TTR; the disease is chronic obstructive pulmonary disease.