The analysis demonstrated that the AFP also had a high accuracy in distinguishing HCC from healthy patients (AUC = 0.844; 95% CI, 0.785 to 0.902; sensitivity 60.2%; specificity 100%), cirrhosis patients (AUC = 0.708; 95% CI, 0.632 to 0.783; sensitivity 57.3%, specificity 79.5%) and control subjects (AUC = 0.766; 95% CI, 0.703 to 0.829; sensitivity 59.2%, specificity 87%). This evidence concerns the gene AFP and Cirrhosis.