Moreover, It has been reported that the EMT-inducing factors, such as TGF-β, PI3K/AKT- and Wnt-signaling [69], [70] produced by the surrounding tumor microenvironment stromal cells [47] can influence the behavior and invasive phenotype in epithelial malignancies initiating of tumor cells. The gene discussed is TGFB1; the disease is neoplasm.