Furthermore, as observed, EMT is identified/characterized by the loss of epithelial properties, including down regulation of cell adhesion molecules like E-cadherin and at the same time promoting of N-cadherin, vimentin, fibronectin, zinc-finger proteins (SNAIL, Slug, ZEB) and matrix metalloproteinases (MMPs) expression, conducting the tumor cells to an higher cell mobility and malignity [48]. Here, CDH2 is linked to neoplasm.