NFKB1 and neoplasm: In this study, we could emphasize that the natural NF-κB inhibitor curcumin is a promising modulator of the synergistic crosstalk in the tumor microenvironment and curcumin-based anti-EMT and tumor progression may be a promising therapeutic strategy to prevent resistance to chemotherapeutic agents, sensitizing CSCs to 5-FU and impede metastasis formation.