Culturing of stromal cells with HCT116 cells in the microenvironment co-culture resulted in an increase of vimentin and decrease of E-cadherin expression in HCT116 cells compared to tumor mono-cultures and the expression of vimentin was considerably inhibited and concomitantly the expression of E-cadherin increased by curcumin in a concentration-dependent manner (Fig. 8D-E). This evidence concerns the gene CDH1 and neoplasm.