ADCYAP1 and glycogen storage disease VI: It is noteworthy that 20% of mice even survived the acute disease for more than 4 weeks when treated prophylactically with PACAP, whereas all control animals had died by day 9.5 p.i. But that time, however, 40% and 80% of mice from the therapeutic and prophylactic PACAP treatment groups, respectively, were still alive.