On the other hand, expression of HNF4α differs with different outcome of HBV infection, being significantly higher in patients with severe hepatitis B(SHB) than those with chronic hepatitis B(CHB) and liver cirrhosis(LC) [26], two well-established risks factors for CHB-associated hepatocarcinogenesis. The gene discussed is HNF4A; the disease is laryngotracheoesophageal cleft.