For example, basal tumors were reported to exhibit high EGFR pathway activity, while mesenchymal tumors, which comprise approximately twenty-five percent of HNSCC, exhibited low EGFR activity; the atypical subtype was enriched in human papillomavirus-related HNSCC; and the classical subtype was shown to be enriched for genes associated with exposure to cigarette smoke [2, 3]. Here, EGFR is linked to head and neck squamous cell carcinoma.