Previous work in the Tg4 TCR-transgenic mouse model, specific for the myelin basic protein (MBP)-derived peptide Ac1–9, demonstrated that augmented differentiation of tTreg cells provides greater resistance to the induction of experimental autoimmune encephalomyelitis (EAE), the murine model of multiple sclerosis (MS) [1]. The gene discussed is MBP; the disease is experimental autoimmune encephalomyelitis.