Moreover, gankyrin knockdown led to a reduction in cell proliferation, colony formation, and cell migration ability in vitro (Fig. 4 C and D) and reduced tumor formation in vivo (LPS 246: 017~03.45 g vs. 2.01~3.99 g, 120~455 mm3 vs. 2000~5115 mm3; SW872: 0.01~0.016 g vs. 0.12~0.35 g, 1~9.37 mm3 vs. 48~200 mm3; Fig. 5). Here, PSMD10 is linked to neoplasm.