In glioma cells, miR451a regulates liver kinase B1 (LKB1)/5′ adenosine monophosphate-activated protein (AMPK) signaling pathway by targeting CAB39 (MO25α) responding to cellular metabolic stress [31] and indirectly inhibiting phosphatidylinositol 3-kinase (PI3K)/AKT pathway [33]. The gene discussed is CAB39; the disease is central nervous system cancer.