On the basis of associations with PCa and significant pathology, ROC curves for the most significant AGR2 transcripts identified an area under the curve (AUC) scores of 0.96, 0.94 and 0.91 for AGR2 SV-H, SV-G and AGR2wt compared to serum PSA (AUC; 0.72) (Figure 5B). Here, KLK3 is linked to posterior cortical atrophy.