LIMK1 and glioblastoma: Of great interest we identified up-regulation of LIM domain kinase 1 and 2 (LIMK1/2) that phosphorylates and inactivates CFL in an additional data set comparing normal brain to GBM (Figure 1C). Lastly, we observed robust expression of LIMK1 in several well-characterized GBM cell lines (U87, T98G and U118) and phospho-CFL in cell lines that expressed LIMK1 (Figure 1D).