However, we found that no obvious difference of VASH1 or Ephrin-B2 expression was observed between EZH2-overexpressed and EZH2-silenced NPC cells (data not shown), suggesting that the alteration of VASH1 and Ephrin-B2 induced by EZH2 was cell type dependent in cancer cells. The gene discussed is EFNB2; the disease is cancer.