For example, resveratrol administration reduces blood pressure in cholesterol-fed swine [130], obese Zucker rats [126], fructose-fed rats [93], the DOCA-salt sensitive rat [125,131], the partially nephrectomized rat [101], two-kidney one-clip hypertensive rat [81], angiotensin-II infused mice [95,103], transgenic rats that overexpress the human renin and angiotensinogen genes [43], as well as in a rat model of pulmonary hypertension [132]. This evidence concerns the gene AGT and pulmonary hypertension.