These results are in contrast with the reduction in anogenital sniffing and/or the number of USVs found in other ASD animal models such as BTBR, En2, NMDA-Nr1, NLG3, NLg4, Dlg4, and FmR1 mice (53, 83–87), but in line with data collected on Shank3 mice, carrying a mutation strongly implicated in autism and Phelan-McDermid 22q13 deletion syndrome, where male knockout mice did not present alterations in social communication and interaction (88). The gene discussed is SHANK3; the disease is autism.