Nelen et al. performed a meta-analysis of 10 case-control studies to assess the risks of hyperhomocysteinemia and MTHFR C677T mutations in recurrent early pregnancy loss and found that elevated blood homocysteine and the variant homozygous genotype 677TT of MTHFR 677 CT polymorphism are risk factors for recurrent early pregnancy loss (13). The gene discussed is MTHFR; the disease is hyperhomocysteinemia.