In Addition, treatment with SOD mimetic has been shown to reduce OS, improve vascular function and structure, and prevent the progression of hypertension in SHR (spontaneously hypertensive rat) via altering the activation of NAD(P)H oxidase and Cu/Zn SOD (25); however, the SOD isoforms, GPX, and CAT reside within the cells that finally lead to elimination of free radicals by generation of water and oxygen (26). This evidence concerns the gene SOD1 and Hypertension.