The most noteworthy SNP may be rs3212986 in ERCC1 gene with reported association with multiple cancer types including, but not limited to, estrogen-related cancers (breast, cervical, and ovarian), smoking-related cancers (lung, esophageal, bladder, head and neck, and pancreatic cancer), and brain tumors. The gene discussed is ERCC1; the disease is pancreatic neoplasm.