Acute-phase reactants were reported to be high in patients with TB although they are not specific to TB.22 Among these reactants, CRP has been suggested as a candidate biomarker for active infection with M. tuberculosis.22,23 Moreover, Kumat et al. reported that CRP, besides other molecules, could be used for distinguishing PTB from EPTB.23 On the contrary to this article; neither CRP nor ESR was found to be high in PTB compared to EPTB in our study. This evidence concerns the gene ESR1 and infection.