Interestingly, the SSc-MSCs production of CTGF was significantly higher when compared with healthy cells and the increased levels of VEGF observed in SSc patients[23] may contribute to the over expression of CTGF, which plays different physiological roles, not only in fibrotic process but also in angiogenesis, such as the maintenance of capillary strength via the extracellular matrix production[66,67]. Here, CCN2 is linked to systemic sclerosis.