The production and level of IL-1α expression is elevated in numerous cancers including head and neck [43], breast [40], pancreatic [44], and gastric cancer [45] and has been associated with virulent tumor phenotype and poorer prognosis via the regulation of inflammatory genes and growth factors to enhance tumor growth and differentiation [46-48] and metastatic potential of cells [49]. The gene discussed is IL1A; the disease is neoplasm.