The impetus for this work appears to stem from the recent inclusion of genes that encode the arylhydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (Nrf2), transcription factors essential to the regulation of the global cellular oxidant control program, among the repertoire of candidates that may be involved in either the predisposition to, or development of, AMD. Here, NFE2L2 is linked to age-related macular degeneration.