Although the employed experimental set-up to test our methodology is somewhat challenging—using a mixture of samples originating from different tissues, mostly cancer tumours—the proposed methodology allowed the identification of loci known to be generally imprinted and involved in genetic and/or imprinting disorders (e.g. IGF2/H19, KCNQ10T1, SNURF/SNRPN, GNAS, ...) demonstrating the robustness and biological relevance of our method. The gene discussed is KCNQ1OT1; the disease is cancer.