We found both miR-221 and miR-222 repressed in late EPCs the levels of chemokine (C-X-C motif) receptor 4 (CXCR4), the receptor for CXCL12 (Figure 4), partly explains why miR-221/222 inhibit late EPC motility (Figure 4C), and EPC levels were reduced in the peripheral blood of CAD patients. Here, CXCL12 is linked to coronary artery disorder.