Induction of EC (endothelial cell) growth, proliferation and survival under stress; induction of migration of ECs during sprouting angiogenesis; increase vascular permeability of ECs; stimulate secretion of proteinases important for tumour invasion and progression; activate matrix degrading enzymes (e.g. metalloproteinases); recruitment of tissue infiltrating hematopoietic cells, modulates receptor-ligand interaction. HIF-1α and angiogenin are transcriptional controller of many of the factors indicated. This evidence concerns the gene ANG and neoplasm.