The latter was compiled by Vogelstein and co-authors [19] according to their “20/20 rule”, which states that a gene can be classified as an oncogene if at least 20% of its recorded mutations are missense mutations that occur at recurrent positions, and as a tumor suppressor gene if at least 20% of its recorded mutations are inactivating. This evidence concerns the gene ENSG00000280371 and neoplasm.