In this study, after clarifying the correlation between NME4 and miR-196 expression in cells (Figures 2A-C), assessing the response of NME4 to miR-196 modulation (Figures 2D), we identified NME4 as a direct target of miR-196a and miR-196b in oral cancer using a luciferase reporter assay (Figure 2E),. This evidence concerns the gene NME4 and lip and oral cavity carcinoma.