HOX family members have been reported primarily, including HOX-B7 (miR-196a target) in melanoma[16], HOX-A (miR-196b target) in acute lymphoblastic leukemia[18], and HOX-C8 (miR-196 family target) in melanoma[11] and breast cancer[15]. The gene discussed is HOXC8; the disease is acute lymphoblastic leukemia.