Genomic analyses in other tumour types have shown that somatic mutations of epigenetic regulators can have important clinical consequences, including improved outcome in patients with DAXX/ATRX alterations in pancreatic neuroendocrine tumours63 and gliomas64, and a decreased survival in patients with ARID1A and ARID1B mutations in neuroblastoma23. Here, ATRX is linked to neoplasm.