While findings from a few studies (e.g., [78]) suggest that exercise reduces systemic inflammation associated with obesity, to our knowledge, this is the first study showing that inflammatory markers (IL-6, IL-8, and TNF-α) in fat tissue of overweight and obese women correlated positively with sedentary activity and negatively with light activity during normal daily life at baseline. Here, IL6 is linked to obesity due to melanocortin 4 receptor deficiency.