While findings from a few studies (e.g., [78]) suggest that exercise reduces systemic inflammation associated with obesity, to our knowledge, this is the first study showing that inflammatory markers (IL-6, IL-8, and TNF-α) in fat tissue of overweight and obese women correlated positively with sedentary activity and negatively with light activity during normal daily life at baseline. The gene discussed is CXCL8; the disease is obesity due to melanocortin 4 receptor deficiency.