Furthermore, it has been demonstrated that MK2−/− mice have a reduced susceptibility for the development of collagen-induced rheumatoid arthritis (RA) [12] and that MK2−/− mice on a Ldlr−/− background are protected against the development of atherosclerosis despite a pro-atherogenic lipoprotein profile [13]. Here, LDLR is linked to rheumatoid arthritis.