Fava et al. [13] recently argued that rs2294757 (T26I), rather than N131S, was a more likely functional variant accounting for the effect on BP because it is located in a splicing regulation site in VNN1, but these investigators only found a weak association between T26I and both DBP and HTN in one of the two studies that they carried out. This evidence concerns the gene VNN1 and hypertensive disorder.